PDGFRα (D842Y) Assay Kit

Platelet-derived growth factor receptor A or PDGFRα has been implicated in regulation of cell growth and survival, apoptosis, and differentiation. It has been identified as a potential target in eosinophilic leukemia cancer, inflammatory breast cancer, and gastrointestinal stromal tumors. The D842 mutation is found in gastrointestinal stromal tumors and mutations at this site, other than D842Y, are associated with resistance to tyrosine kinase inhibitors. The PDGFRα (D842Y) Assay Kit is designed to measure PDGFRα (D842Y) activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent.