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Doramapimod

  • 产品型号:27034
  • 厂商性质:生产厂家
  • 更新时间:2024-01-31
  • 访  问  量:142
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Description

Doramapimod is a protein kinase inhibitor with a >330-fold selectivity for p38 MAPK compared with 12 other protein kinases. Doramapimod prevents both the kinetic activity and phosphorylation of p38 MAPK by binding to the ATP pocket as well as to a novel allosteric binding site on p38 MAPK. Doramapimod also blocks proliferation of cells expressing BCR-ABL(T315I), with an IC50 of 2-3 µM.

Synonyms
BIRB 796
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