

●Purchase●DescriptionSMI-4aisapotentinhibitorofPim1withIC50=17-21nM
产品型号:27774-1
厂商性质:生产厂家
更新时间:2023-11-13
访 问 量:187
立即咨询
联系电话:
SMI-4a is a potent inhibitor of Pim1 with IC50 = 17 -21 nM. It does not significantly inhibit other serine/threonine- or tyrosine-kinases. It induces G1 phase cell cycle arrest and induces apoptosis through the mitocondrial pathway. It downregulates c-myc and induces p27Kip1 expression. Inhibits PRAS40 phosphorylation and mTOR activity, as well as the mammalian target of rapamycin C1 (mTORC1) pathway. SMI-4a is a potential anti-cancer compound that blocks prostate cancer growth.