Panobinostat

●Purchase●DescriptionPanobinostat,alsoknownasLBH-589,isahighlyactive,non-selectiveHDACinhibitor

产品型号：27020
厂商性质：生产厂家
更新时间：2023-11-11
访问量：146

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Description

Panobinostat, also known as LBH-589, is a highly active, non-selective HDAC inhibitor. IC50’s against HDAC s 1-9 range between 3 – 61 nM except for a slightly higher IC50 value of 248 nM for HDAC 8. Panobinostat inhibits tumor cell proliferation and induces apoptosis in breast cancer and T cell lymphoma cells. In addition to its tumor-suppressive activities, panobinostat induces histone H3K9 and histone H4K8 acetylation and decreases the level of c-Myc expression.

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Synonyms

Faridak, LBH-589

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Panobinostat

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