XL-888

●Purchase●DescriptionXL-888isanovelandorally-bioavailableinhibitorofheatshockprotein90(HSP90)thatselectivelyinhibitsHSP90andHSP90withIC50sof22nMand44nMrespectively

产品型号：27781-3
厂商性质：生产厂家
更新时间：2023-11-10
访问量：194

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Description

XL-888 is a novel and orally-bioavailable inhibitor of heat shock protein 90 (HSP90) that selectively inhibits HSP90α and HSP90β with IC50s of 22 nM and 44 nM respectively. It also exerts considerably weaker inhibition against a range of other diverse kinases with IC50 more than 3600 nM for all. In recent studies, XL-888 has exhibits strong anti-proliferative activities in a panel of tumor cells with values of IC50 ranging from 0.1 nM to 45.5 nM.

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Synonyms

Xl 888; Xl888; 2-(butan-2-ylamino)-4-N-[(1R,5S)-8-[5-(cyclopropanecarbonyl)pyridin-2-yl]-8-azabicyclo[3.2.1]octan-3-yl]-5-methylbenzene-1,4-dicarboxamide

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XL-888

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