AAV3 Luciferase-eGFP

保存条件：-80°C(dryice)保质期：3-18month英文名：AAV3Luciferase-eGFP数量：1供应商：BPSBioscienceInc

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厂商性质：生产厂家
更新时间：2023-10-10
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详细介绍

保存条件：
-80°C (dry ice)
保质期：
3-18 month
英文名：
AAV3 Luciferase-eGFP
数量：
1
供应商：
BPS Bioscience Inc.
CAS号：
/
规格：
50 µl x 2

Adeno-Associated Virus Serotype 3 (AAV3) shares 82% sequence homology with AAV2, and like AAV2, requires Heparan Sulfate Proteoglycan (HSPG) for cellular attachment. AAV3 vectors transduce human liver cancer cells extremely efficiently because AAV3 utilizes the human Hepatocyte Growth Factor Receptor (hHGFR) as a co-receptor for viral entry, which is highly expressed in these cells. Both the extracellular domain and the intracellular kinase domain of hHGFR are required for AAV3-mediated transgene expression. These AAV3 particles constitutively express the firefly (Photinus pyralis) luciferase and eGFP genes connected via a T2A linker, under the control of a CMV promoter. The T2A self-cleaving peptide (derived from Thosea asigna virus 2A) leads to the efficient cleavage of the transcript, and expression of luciferase and eGFP as two separate proteins.

温馨提示：不可用于临床治疗。

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